Transcriptomic analysis highlights cochlear inflammation associated with age-related hearing loss in C57BL/6 mice using next generation sequencing.

ABSTRACT:

Background

In our aging society, age-related hearing loss (AHL) is the most common sensory disorder in old people. Much progress has been made in understanding the pathological process of AHL over the past few decades. However, the mechanism of cochlear degeneration during aging is still not fully understood.

Methods

Next generation sequencing technique was used to sequence the whole transcriptome of the cochlea of C57BL/6 mice, a mouse model of AHL. Differentially expressed genes (DEGs) were identified using the Cuffdiff software. GO and KEGG pathway enrichment analyses of the DEGs were implemented by using the GOseq R package and KOBAS software, respectively.

Results

A total of 731 genes (379 up- and 352 down-regulated) were revealed to be differentially expressed i

SUBMITTER: Su Z 

PROVIDER: S-EPMC7443093 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature