A newly isolated strain of Halomonas sp. (HA1) exerts anticancer potential via induction of apoptosis and G₂/M arrest in hepatocellular carcinoma (HepG2) cell line.

ABSTRACT: Marine bacterial strains are of great interest for their ability to produce secondary metabolites with anticancer potentials. Isolation, identification, characterization and anticancer activities of isolated bacteria from El-Hamra Lake, Wadi El-Natrun (Egypt) were the objectives of this study. The isolated bacteria were identified as a moderately halophilic alkaliphilic strain. Ethyl acetate extraction was performed and identified by liquid chromatography-mass spectrophotometry (LC-MS-MS) and nuclear magnetic resonance analysis (NMR). Cytotoxicity of the extract was assessed on the HepG2 cell line and normal human peripheral lymphocytes (HPBL) in vitro. Halomonas sp. HA1 extract analyses revealed anticancer potential. Many compounds have been identified including cyclo-(Leu-Leu), cyclo-(Pr

SUBMITTER: El-Garawani IM 

PROVIDER: S-EPMC7443142 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature