Associations between aversive learning processes and transdiagnostic psychiatric symptoms in a general population sample.

ABSTRACT: Symptom expression in psychiatric conditions is often linked to altered threat perception, however how computational mechanisms that support aversive learning relate to specific psychiatric symptoms remains undetermined. We answer this question using an online game-based aversive learning task together with measures of common psychiatric symptoms in 400 subjects. We show that physiological symptoms of anxiety and a transdiagnostic compulsivity-related factor are associated with enhanced safety learning, as measured using a probabilistic computational model, while trait cognitive anxiety symptoms are associated with enhanced learning from danger. We use data-driven partial least squares regression to identify two separable components across behavioural and questionnaire data: one linking en

SUBMITTER: Wise T 

PROVIDER: S-EPMC7443146 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature