MicroRNA-451 as an Early Predictor of Chronic Kidney Disease in Diabetic Nephropathy.

ABSTRACT:

Background

Diabetes mellitus is the leading cause of end-stage renal disease worldwide. Microalbuminuria is the cornerstone for the diagnosis of diabetic nephropathy. However, it is an inadequate marker for early diagnosis. MicroRNAs are not only new and promising markers for early diagnosis but also, but they may also play a role in the prevention of disease progression.

Methods

This study included ninety patients with type 2 DM in addition to 30 control subjects. MicroRNA-451 expression in blood and plasma using real-time PCR was evaluated in addition to the classic diabetic nephropathy markers (serum creatinine, urinary albumin, and eGFR).

Results

There was a significant difference between the studied groups versus control regarding serum creatinine, eGFR, urinary,

SUBMITTER: Abdelsalam M 

PROVIDER: S-EPMC7443237 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature