Anti-inflammatory IL-10 administration rescues depression-associated learning and memory deficits in mice.

ABSTRACT:

Background

Major depressive disorder is a widespread mood disorder. One of the most debilitating symptoms patients often experience is cognitive impairment. Recent findings suggest that inflammation is associated with depression and impaired cognition. Pro-inflammatory cytokines are elevated in the blood of depressed patients and impair learning and memory processes, suggesting that an anti-inflammatory approach might be beneficial for both depression and cognition.

Methods

We subjected mice to the learned helplessness paradigm and evaluated novel object recognition and spatial memory. Mice were treated with IL-10 intranasally or/and microglia cells were depleted using PLX5622. Statistical differences were tested using ANOVA or t tests.

Results

We first established a

SUBMITTER: Worthen RJ 

PROVIDER: S-EPMC7443292 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature