IKBKB rs2272736 is Associated with Gastric Cancer Survival.

ABSTRACT:

Background

IKBKB/IKKβ, as the core catalytic subunit of IκB kinase complex, participates in mediation of the classical NF-κB pathway, which has been linked to inflammation and tumorigenesis. Previous studies have shown that single nucleotide polymorphisms in IKBKB have been related to gastric cancer, but how they associate to the clinical outcome is not yet clear. In this study, we retrospectively investigated the associations between single nucleotide polymorphisms located in IKBKB and gastric cancer survival.

Materials and methods

IKBKB rs2272736 was genotyped in 1210 patients with primary gastric cancer in a Han Chinese population, and the relationships between rs2272736 and overall survival were evaluated. We conducted Cox proportional hazards regression, which was perfo

SUBMITTER: Gong Y 

PROVIDER: S-EPMC7443400 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature