Desmopressin responsiveness by age in type 1 von Willebrand disease.

ABSTRACT:

Background

Patients with type 1 von Willebrand disease (VWD) undergo a desmopressin (DDAVP) responsiveness challenge at diagnosis to assess whether DDAVP reverses their coagulation deficits. Current practice assumes DDAVP responsiveness remains constant over the lifetime. In patients with type 1 VWD, VWF-related parameters increase with age. This study explores whether DDAVP responsiveness also differs with age in this population.

Methods

We conducted a retrospective chart review of 106 patients enrolled at our center since 1990. Our primary outcome was DDAVP responsiveness at 1 hour after DDAVP challenge. Locally weighted scatterplot smoothing fit and Spearman correlation coefficients were used to study the relationship between age and DDAVP responsiveness. For female parti

SUBMITTER: Goldberg N 

PROVIDER: S-EPMC7443436 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature