Transient stimulation of TRPV4-expressing keratinocytes promotes hair follicle regeneration in mice.

ABSTRACT:

Background and purpose

Hair follicle telogen to anagen transition results in a break in cellular quiescence of the hair follicle stem cells, which subsequently promotes hair follicle regeneration. Many critical molecules and signalling pathways are involved in hair follicle cycle progression. Transient receptor potential vanilloid 4 (TRPV4) is a polymodal sensory transducer that regulates various cutaneous functions under both normal and disease conditions. However, the role of TRPV4 in hair follicle regeneration in vivo remains incompletely understood.

Experimental approach

Using adult C57BL/6J mice, keratinocyte (K14^Cre ; Trpv4^f/f ) and macrophage (Cx3cr1^Cre ; Trpv4^f/f ) Trpv4 conditional knockout (cKO) mice, Trpv4^-/-

SUBMITTER: Yang P 

PROVIDER: S-EPMC7443470 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature