Sensitization of glutamate receptor-mediated pain behaviour via nerve growth factor-dependent phosphorylation of transient receptor potential V1 under inflammatory conditions.

ABSTRACT:

Background and purpose

Glutamate and metabotropic glutamate (mGlu) receptors on primary sensory neurons are crucial in modulating pain sensitivity. However, it is unclear how inflammation affects mGlu receptor-mediated nociceptive responses. We therefore investigated the effects of mGlu_1/5 receptor agonists on pain-related behaviour during persistent inflammation and their underlying mechanisms.

Experimental approach

Effects of a mGlu_1/5 receptor agonist on pain-related behaviour during inflammation was assessed in mice. Intracellular calcium responses, membrane current responses, and protein expression in primary sensory neurons were examined using cultured dorsal root ganglion (DRG) neurons, dissociated from wild-type and gene knockout mice.

Key re

SUBMITTER: Masuoka T 

PROVIDER: S-EPMC7443478 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature