Corticosteroid therapy for critically ill patients with COVID-19: A structured summary of a study protocol for a prospective meta-analysis of randomized trials.

ABSTRACT:

Objectives

Primary objective: To estimate the effect of corticosteroids compared with usual care or placebo on mortality up to 28 days after randomization. Secondary objectives: To examine whether the effect of corticosteroids compared with usual care or placebo on mortality up to 28 days after randomization varies between subgroups related to treatment characteristics, disease severity at the time of randomization, patient characteristics, or risk of bias. To examine the effect of corticosteroids compared with usual care or placebo on serious adverse events.

Study design

Prospective meta-analysis of randomized controlled trials. Both placebo-controlled and open-label trials are eligible.

Participants

Hospitalised, critically ill patients with suspected or confirmed C

SUBMITTER: Sterne JAC 

PROVIDER: S-EPMC7443535 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature