Identification of potential drugs against SARS-CoV-2 non-structural protein 1 (nsp1).

ABSTRACT: Non-structural protein 1 (nsp1) is found in all Betacoronavirus genus, an important viral group that causes severe respiratory human diseases. This protein has significant role in pathogenesis and it is considered a probably major virulence factor. As it is absent in humans, it becomes an interesting target of study, especially when it comes to the rational search for drugs, since it increases the specificity of the target and reduces possible adverse effects that may be caused to the patient. Using approaches in silico we seek to study the behavior of nsp1 in solution to obtain its most stable conformation and find possible drugs with affinity to all of them. For this purpose, complete model of nsp1 of SARS-CoV-2 were predicted and its stability analyzed by molecular dynamic

SUBMITTER: de Lima Menezes G 

PROVIDER: S-EPMC7443570 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature