Complete Connectomic Reconstruction of Olfactory Projection Neurons in the Fly Brain.

ABSTRACT: Nervous systems contain sensory neurons, local neurons, projection neurons, and motor neurons. To understand how these building blocks form whole circuits, we must distil these broad classes into neuronal cell types and describe their network connectivity. Using an electron micrograph dataset for an entire Drosophila melanogaster brain, we reconstruct the first complete inventory of olfactory projections connecting the antennal lobe, the insect analog of the mammalian olfactory bulb, to higher-order brain regions in an adult animal brain. We then connect this inventory to extant data in the literature, providing synaptic-resolution "holotypes" both for heavily investigated and previously unknown cell types. Projection neurons are approximately twice as numerous as reported by light level s

SUBMITTER: Bates AS 

PROVIDER: S-EPMC7443706 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature