Optimization of flucloxacillin dosing regimens in critically ill patients using population pharmacokinetic modelling of total and unbound concentrations.

ABSTRACT:

Background

Initial appropriate anti-infective therapy is associated with improved outcomes in patients with severe infections. In critically ill patients, altered pharmacokinetic (PK) behaviour is common and known to influence the achievement of PK/pharmacodynamic targets.

Objectives

To describe population PK and optimized dosing regimens for flucloxacillin in critically ill patients.

Methods

First, we developed a population PK model, estimated between-patient variability (BPV) and identified covariates that could explain BPV through non-linear mixed-effects analysis, using total and unbound concentrations obtained from 35 adult critically ill patients treated with intermittent flucloxacillin. Second, we validated the model using external datasets from two different c

SUBMITTER: Jager NGL 

PROVIDER: S-EPMC7443729 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature