Detection of heterogeneous vancomycin intermediate resistance in MRSA isolates from Latin America.

ABSTRACT:

Background

Vancomycin is a common first-line option for MRSA infections. The heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) phenotype is associated with therapeutic failure. However, hVISA isolates are usually reported as vancomycin susceptible by routine susceptibility testing procedures.

Objectives

To detect and characterize the hVISA phenotype in MRSA isolates causing infections in nine Latin American countries.

Methods

We evaluated a total of 1189 vancomycin-susceptible MRSA isolates recovered during 2006-08 and 2011-14. After an initial screening of hVISA using glycopeptide-supplemented agar strategies, the detection of hVISA was performed by Etest (GRD) and Macro-method (MET). Isolates deemed to be hVISA were subjected to population analysis

SUBMITTER: Castro BE 

PROVIDER: S-EPMC7443737 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature