CSF glucose tracks regional tau progression based on Alzheimer's disease risk factors.

ABSTRACT:

Introduction

Glucose hypometabolism and tau formation are key features of Alzheimer's disease (AD). Less is known about the relationship between fasting glucose and regional tau accumulation.

Methods

Cerebrospinal fluid (CSF) glucose was linearly regressed on regional tau (flortaucipir) among 169 Alzheimer's Disease Neuroimaging Initiative (ADNI3) participants. Flortaucipir uptake was examined by Braak stages and regions of interest (ROIs). Interactions were explored between CSF glucose and AD risk factors including regional amyloid beta (Aβ), sex, Apolipoprotein E ε4 (APOEε4) status, AD parental family history (AD FH), and cognitive impairment (CI).

Results

Interactions found higher CSF glucose tracked less tau in ROIs or Braak stages I/II (women, APOE

SUBMITTER: Pappas C 

PROVIDER: S-EPMC7443745 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature