Is cognitive dysfunction involved in difficult-to-treat depression? Characterizing resistance from a cognitive perspective.

ABSTRACT:

Background

This study aimed to identify clinical and cognitive factors associated with increased risk for difficult-to-treat depression (DTD) or treatment-resistant depression (TRD).

Methods

A total of 229 adult outpatients with major depression were recruited from the mental health unit at a public hospital. Participants were subdivided into resistant and nonresistant groups according to their Maudsley Staging Model score. Sociodemographic, clinical, and cognitive (objective and subjective measures) variables were compared between groups, and a logistic regression model was used to identify the factors most associated with TRD risk.

Results

TRD group patients present higher verbal memory impairment than the nonresistant group irrespective of pharmacological treatment

SUBMITTER: Lopez-Sola C 

PROVIDER: S-EPMC7443785 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature