Regulatory T cells suppress Th17 cell Ca²⁺ signaling in the spinal cord during murine autoimmune neuroinflammation.

ABSTRACT: T lymphocyte motility and interaction dynamics with other immune cells are vital determinants of immune responses. Regulatory T (Treg) cells prevent autoimmune disorders by suppressing excessive lymphocyte activity, but how interstitial motility patterns of Treg cells limit neuroinflammation is not well understood. We used two-photon microscopy to elucidate the spatial organization, motility characteristics, and interactions of endogenous Treg and Th17 cells together with antigen-presenting cells (APCs) within the spinal cord leptomeninges in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. Th17 cells arrive before the onset of clinical symptoms, distribute uniformly during the peak, and decline in numbers during later stages of EAE. In contrast, Treg

SUBMITTER: Othy S 

PROVIDER: S-EPMC7443932 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature