A novel tsRNA-16902 regulating the adipogenic differentiation of human bone marrow mesenchymal stem cells.

ABSTRACT:

Background

Transfer RNA-derived small RNAs (tsRNAs) are a recently discovered form of non-coding RNA capable of regulating myriad physiological processes. The role of tsRNAs in hMSC adipogenic differentiation, however, remains incompletely understood. The purpose of this study was to identify the novel tsRNA-16902 as a regulator of hMSC adipogenic differentiation.

Methods

In this study, we conducted transcriptomic sequencing of hMSCs after inducing their adipogenic differentiation, and we were thereby able to clarify the molecular mechanism underlying the role of tsRNA-16902 in this context via a series of molecular biology methods.

Results

When we knocked down tsRNA-16902 expression, this impaired hMSC adipogenic differentiation and associated marker gene expression.

SUBMITTER: Wang T 

PROVIDER: S-EPMC7444066 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature