Sex differences in circulating proteins in heart failure with preserved ejection fraction.

ABSTRACT:

Background

Many patients with heart failure with preserved ejection fraction (HFpEF) are women. Exploring mechanisms underlying the sex differences may improve our understanding of the pathophysiology of HFpEF. Studies focusing on sex differences in circulating proteins in HFpEF patients are scarce.

Methods

A total of 415 proteins were analyzed in 392 HFpEF patients included in The Metabolic Road to Diastolic Heart Failure: Diastolic Heart Failure study (MEDIA-DHF). Sex differences in these proteins were assessed using adjusted logistic regression analyses. The associations between candidate proteins and cardiovascular (CV) death or CV hospitalization (with sex interaction) were assessed using Cox regression models.

Results

We found 9 proteins to be differentially exp

SUBMITTER: Stienen S 

PROVIDER: S-EPMC7444077 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature