Epstein-Barr virus infection in ulcerative colitis: a clinicopathologic study from a Chinese area.

ABSTRACT:

Background

Opportunistic Epstein-Barr virus (EBV) infection in patients with ulcerative colitis (UC) has attracted increasing attention. This study aimed to evaluate the clinicopathological characteristics and clinical outcomes of UC with intestinal EBV infection and to explore the predictive value of blood EBV DNA for the presence of EBV in the intestine.

Methods

Both peripheral blood and intestinal biopsies from 92 consecutive UC inpatients were included in this study. Normal colonic mucosal tissues from 20 colon cancer patients were used as controls. EBV testing and assessment were performed by EBV-DNA polymerase chain reaction (PCR), EBV-encoded small RNA in situ hybridization (EBER-ISH) and immunohistochemistry.

Results

A total of 36 patients (39.1%) had U

SUBMITTER: Xu S 

PROVIDER: S-EPMC7444145 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature