Gene co-expression and histone modification signatures are associated with melanoma progression, epithelial-to-mesenchymal transition, and metastasis.

ABSTRACT:

Background

We have previously developed a murine cellular system that models the transformation from melanocytes to metastatic melanoma cells. This model was established by cycles of anchorage impediment of melanocytes and consists of four cell lines: differentiated melanocytes (melan-a), pre-malignant melanocytes (4C), malignant (4C11-), and metastasis-prone (4C11+) melanoma cells. Here, we searched for transcriptional and epigenetic signatures associated with melanoma progression and metastasis by performing a gene co-expression analysis of transcriptome data and a mass-spectrometry-based profiling of histone modifications in this model.

Results

Eighteen modules of co-expressed genes were identified, and some of them were associated with melanoma progression, epithelial-to

SUBMITTER: Azevedo H 

PROVIDER: S-EPMC7444266 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature