Macrophages in Systemic Sclerosis: Novel Insights and Therapeutic Implications.

ABSTRACT:

Purpose of review

Macrophages play key roles in tissue homeostasis and immune surveillance, mobilizing immune activation in response to microbial invasion and promoting wound healing to repair damaged tissue. However, failure to resolve macrophage activation can lead to chronic inflammation and fibrosis, and ultimately to pathology. Activated macrophages have been implicated in the pathogenesis of systemic sclerosis (SSc), although the triggers that induce immune activation in SSc and the signaling pathways that underlie aberrant macrophage activation remain unknown.

Recent findings

Macrophages are implicated in fibrotic activation in SSc. Targeted therapeutic interventions directed against SSc macrophages may ameliorate inflammation and fibrosis. While current studies have

SUBMITTER: Toledo DM 

PROVIDER: S-EPMC7444604 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature