Blood pressure in frail older adults: associations with cardiovascular outcomes and all-cause mortality.

ABSTRACT:

Background

Blood pressure (BP) management in frail older people is challenging. An randomised controlled trial of largely non-frail older people found cardiovascular and mortality benefit with systolic (S) BP target <120 mmHg. However, all-cause mortality by attained BP in routine care in frail adults aged above 75 is unclear.

Objectives

To estimate observational associations between baseline BP and mortality/cardiovascular outcomes in a primary-care population aged above 75, stratified by frailty.

Methods

Prospective observational analysis using electronic health records (clinical practice research datalink, n = 415,980). We tested BP associations with cardiovascular events and mortality using competing and Cox proportional-hazards models respectively (follow-up ≤10 

SUBMITTER: Masoli JAH 

PROVIDER: S-EPMC7444671 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature