Altered Sensitivity to Motion of Area MT Neurons Following Long-Term V1 Lesions.

ABSTRACT: Primates with primary visual cortex (V1) damage often retain residual motion sensitivity, which is hypothesized to be mediated by middle temporal area (MT). MT neurons continue to respond to stimuli shortly after V1 lesions; however, experimental and clinical studies of lesion-induced plasticity have shown that lesion effects can take several months to stabilize. It is unknown what physiological changes occur in MT and whether neural responses persist long after V1 damage. We recorded neuronal responses in MT to moving dot patterns in adult marmoset monkeys 6-12 months after unilateral V1 lesions. In contrast to results obtained shortly after V1 lesions, we found that fewer MT neurons were direction selective, including neurons expected to still receive projections from remaining parts of

SUBMITTER: Hagan MA 

PROVIDER: S-EPMC7444738 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature