Topical fibroblast growth factor-2 for treatment of chronic tympanic membrane perforations.

ABSTRACT:

Objective

To determine the efficacy of fibroblast growth factor-2 (FGF-2) in treating chronic nonhealing tympanic membrane (TM) perforations.

Method

Double-blinded, randomized placebo controlled phase 2 clinical trial for patients with chronic TM perforations of more than 3 months duration with a cross-over arm. Patients received either FGF-2 or placebo (sterile water) saturated gelatin sponge in the perforation after rimming the perforation under topical anesthesia. The perforation was then covered with Tisseel fibrin glue. The primary endpoint was complete closure of the TM perforation. Secondary end points included change in hearing and partial TM closure rates. The TM was examined every 3 weeks with otoendoscopy for closure. The treatment was repeated if there was incomp

SUBMITTER: Santos F 

PROVIDER: S-EPMC7444771 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature