Concomitant benzodiazepine and opioids decrease sleep apnoea risk in chronic pain patients.

ABSTRACT:

Background

The concurrent use of sedating centrally acting drugs and opioids by chronic pain patients occurs routinely despite concerns of negative impacts on respiration during sleep. The effects of centrally acting drugs and opioids on sleep apnoea have not been well characterised. The objective of this study was to assess the effect of concomitant centrally acting drugs and opioids on the prevalence and severity of sleep apnoea in chronic pain patients.

Methods

We conducted a prospective cohort study at five chronic pain clinics. Each participant underwent an in-laboratory polysomnography and daily morphine milligram equivalents were calculated. Participants were grouped into centrally acting drugs and opioid users versus sole opioid users.

Results

Of the 33

SUBMITTER: Mir S 

PROVIDER: S-EPMC7445118 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature