Polygenic risk for anxiety influences anxiety comorbidity and suicidal behavior in bipolar disorder.

ABSTRACT: Bipolar disorder is often comorbid with anxiety, which is itself associated with poorer clinical outcomes, including suicide. A better etiologic understanding of this comorbidity could inform diagnosis and treatment. The present study aims to test whether comorbid anxiety in bipolar disorder reflects shared genetic risk factors. We also sought to assess the contribution of genetic risk for anxiety to suicide attempts in bipolar disorder. Polygenic risk scores (PRS) were calculated from published genome-wide association studies of samples of controls and cases with anxiety (n = 83,566) or bipolar disorder (n = 51,710), then scored in independent target samples (total n = 3369) of individuals with bipolar disorder who reported or denied lifetime anxiety disorders or suicidal attempts in rese

SUBMITTER: Lopes FL 

PROVIDER: S-EPMC7445247 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature