Childhood trauma, suicide risk and inflammatory phenotypes of depression: insights from monocyte gene expression.

ABSTRACT: Circulating monocytes contribute to inflammatory processes. We here validate abnormal expression of inflammation-related genes in monocytes of a large and well-characterised group of MDD patients, and relate the outcomes to pertinent clinical characteristics. Thirty-two genes of a previously established inflammation-related gene signature were assessed in 197 patients with MDD, and 151 controls collected during the EU-MOODINFLAME project. Monocyte gene- expression data were related to age, sex, BMI, depression severity, childhood adversity (CA) and suicide risk (SR). Three distinct gene profiles were identified within the MDD group (downregulated, mixed upregulated and strongly upregulated genes). Patients in the merged upregulated groups had a significantly higher prevalence of CA and hig

SUBMITTER: Schiweck C 

PROVIDER: S-EPMC7445278 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature