RNA processing genes characterize RNA splicing and further stratify colorectal cancer.

ABSTRACT:

Objectives

Due to the limited evaluation of the prognostic value of RNA processing genes (RPGs), which are regulators of alternative splicing events (ASEs) that have been shown to be associated with tumour progression, this study sought to determine whether colorectal cancer (CRC) could be further stratified based on the expression pattern of RPGs.

Materials and methods

The gene expression profiles of CRCs were collected from TCGA (training set) and three external validation cohorts, representing 1060 cases totally. Cox regression with least absolute shrinkage and selection operator (LASSO) penalty was used to develop an RNA processing gene index (RPGI) risk score. Kaplan-Meier curves, multivariate Cox regression and restricted mean survival (RMS) analyses were harnessed to

SUBMITTER: Lu X 

PROVIDER: S-EPMC7445406 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature