Comparison of ¹⁸F-FDG PET-MR and fecal biomarkers in the assessment of disease activity in patients with ulcerative colitis.

ABSTRACT:

Objective

To compare the diagnostic performance of fecal biomarkers and ¹⁸F-fludeoxyglucose (¹⁸F-FDG) positron emmision tomography-MR (PET-MR) in the assessment of disease activity in patients with ulcerative colitis.

Methods

This study was conducted under the framework of a single-center clinical trial (clinicaltrials.gov [NCT03781284]). N = 50 participants were enrolled. Fecal samples were collected before bowel preparation. All patients underwent whole-body ¹⁸F-FDG PET-MR followed by ileocolonoscopy within 24 h. Diagnostic performance of five fecal biomarkers (calprotectin, lactoferrin, polymorphonuclear leukocyte elastase, S100A12 and eosinophil-derived neurotoxin), MR morphological parameters (MRmorph), diffusion-weighted imaging

SUBMITTER: Li Y 

PROVIDER: S-EPMC7446018 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature