Induction of microvascular network growth in the mouse mesentery.

ABSTRACT:

Objective

Motivated by observations of mesenteries harvested from mice treated with tamoxifen dissolved in oil for inducible gene mutation studies, the objective of this study was to demonstrate that microvascular growth can be induced in the avascular mouse mesentery tissue.

Methods

C57BL/6 mice were administered an IP injection for five consecutive days of: saline, sunflower oil, tamoxifen dissolved in sunflower oil, corn oil, or peanut oil.

Results

Twenty-one days post-injection, zero tissues from saline group contained branching microvascular networks. In contrast, all tissues from the three oils and tamoxifen groups contained vascular networks with arterioles, venules, and capillaries. Smooth muscle cells and pericytes were present in their expected locations and

SUBMITTER: Suarez-Martinez AD 

PROVIDER: S-EPMC7446122 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature