Osteopontin promoter polymorphisms and risk of urolithiasis: a candidate gene association and meta-analysis study.

ABSTRACT:

Background

Urolithiasis is a worldwide urological problem with significant contribution of genetic factors. Pakistan, which resides within the Afro-Asian stone belt, has a high reported prevalence (12%) of urolithiasis. Osteopontin (SPP1) is a urinary macromolecule with a suggested critical role in modulating renal stone formation, genetic polymorphisms of which may determine individual risk of developing urolithiasis. However, results of previous studies regarding SPP1 polymorphisms and susceptibility to urolithiasis have apparent inconsistencies with no data available for local population.

Methods

A total of 235 urolithiasis patients and 243 healthy controls, all of Pakistani ancestry, underwent genotyping for six SPP1 genetic polymorphisms in an effort to investigate pote

SUBMITTER: Amar A 

PROVIDER: S-EPMC7446165 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature