Impact of plasma potassium normalization on short-term mortality in patients with hypertension and hypokalemia or low normal potassium.

ABSTRACT:

Background

Hypokalemia is common in patients treated with antihypertensive drugs, but the impact of correcting hypokalemia is insufficiently studied. We examined the consequences of hypokalemia and borderline hypokalemia correction in patients with hypertension.

Methods

We identified 8976 patients with hypertension and plasma potassium concentrations ≤3.7 mmol/L within 100 days from combination antihypertensive therapy initiation. The first measurement between 6 and 100 days after the episode with potassium ≤3.7 mmol/L was retained. We investigated all-cause and cardiovascular mortality within 60-days from the second potassium measurement using Cox regression. Mortality was examined for seven predefined potassium intervals derived from the second measurement: 1.5-2.9 mmol/L

SUBMITTER: Krogager ML 

PROVIDER: S-EPMC7446172 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature