Post-diagnostic antipsychotic use and cancer mortality: a population based cohort study.

ABSTRACT:

Background

Many antipsychotics elevate prolactin, a hormone implicated in breast cancer aetiology however no studies have investigated antipsychotic use in patients with breast cancer. This study investigated if antipsychotic use is associated with an increased risk of cancer-specific mortality among breast cancer patients.

Methods

A cohort of 23,695 women newly diagnosed with a primary breast cancer between 1st January 1998 and 31st December 2012 was identified from the UK Clinical Practice Research Datalink linked to English cancer-registries and followed for until 30th September 2015. Time-dependent Cox proportional hazards models were used to calculate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of breast cancer-specific mortality comparing use of ant

SUBMITTER: Hicks BM 

PROVIDER: S-EPMC7446212 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature