Predictive Biomarkers in Metastatic Colorectal Cancer: A Systematic Review.

ABSTRACT: The development and use of predictive biomarkers to guide treatment decisions are paramount not only for improving survival in patients with metastatic colorectal cancer (mCRC), but also for sparing them from unnecessary toxicity and reducing the economic burden of expensive treatments. We conducted a systematic review of published studies and evaluated the predictive biomarker landscape in the mCRC setting from a molecular and clinical viewpoint. Studies analyzing predictive biomarkers for approved therapies in patients with mCRC were identified systematically using electronic databases. Preclinical studies and those providing no relevant information were excluded. A total of 173 studies comprising 148 biomarkers were selected for final analysis. Of all the biomarkers analyzed, 1.4% (two

SUBMITTER: Ruiz-Banobre J 

PROVIDER: S-EPMC7446314 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature