High long-term test-retest reliability for extrastriatal ¹¹C-raclopride binding in healthy older adults.

ABSTRACT: In vivo dopamine D2-receptor availability is frequently assessed with ¹¹C-raclopride and positron emission tomography. Due to low signal-to-noise ratios for ¹¹C-raclopride in areas with low D2 receptor densities, the ligand has been considered unreliable for measurements outside the dopamine-dense striatum. Intriguingly, recent studies show that extrastriatal ¹¹C-raclopride binding potential (BP_ND) values are (i) reliably higher than in the cerebellum (where D2-receptor levels are negligible), (ii) correlate with behavior in the expected direction, and (iii) showed good test-retest reliability in a sample of younger adults. The present work demonstrates high seven-month test-retest reliability of striatal and extrastriatal ¹¹C-raclopri

SUBMITTER: Karalija N 

PROVIDER: S-EPMC7446562 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature