Different preprocessing strategies lead to different conclusions: A [¹¹C]DASB-PET reproducibility study.

ABSTRACT: Positron emission tomography (PET) neuroimaging provides unique possibilities to study biological processes in vivo under basal and interventional conditions. For quantification of PET data, researchers commonly apply different arrays of sequential data analytic methods ("preprocessing pipeline"), but it is often unknown how the choice of preprocessing affects the final outcome. Here, we use an available data set from a double-blind, randomized, placebo-controlled [¹¹C]DASB-PET study as a case to evaluate how the choice of preprocessing affects the outcome of the study. We tested the impact of 384 commonly used preprocessing strategies on a previously reported positive association between the change from baseline in neocortical serotonin transporter binding determined with [

SUBMITTER: Norgaard M 

PROVIDER: S-EPMC7446563 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature