Use of hydroxychloroquine in hospitalised COVID-19 patients is associated with reduced mortality: Findings from the observational multicentre Italian CORIST study.

ABSTRACT:

Background

Hydroxychloroquine (HCQ) was proposed as potential treatment for COVID-19.

Objective

We set-up a multicenter Italian collaboration to investigate the relationship between HCQ therapy and COVID-19 in-hospital mortality.

Methods

In a retrospective observational study, 3,451 unselected patients hospitalized in 33 clinical centers in Italy, from February 19, 2020 to May 23, 2020, with laboratory-confirmed SARS-CoV-2 infection, were analyzed. The primary end-point in a time-to event analysis was in-hospital death, comparing patients who received HCQ with patients who did not. We used multivariable Cox proportional-hazards regression models with inverse probability for treatment weighting by propensity scores, with the addition of subgroup analyses.

Results

SUBMITTER: COVID-19 RISK and Treatments (CORIST) Collaboration 

PROVIDER: S-EPMC7446618 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature