Harnessing antifungal immunity in pursuit of a Staphylococcus aureus vaccine strategy.

ABSTRACT: Staphylococcus aureus (S. aureus) is one of the most common bacterial infections worldwide, and antibiotic resistant strains such as Methicillin-Resistant S. aureus (MRSA) are a major threat and burden to public health. MRSA not only infects immunocompromised patients but also healthy individuals and has rapidly spread from the healthcare setting to the outside community. However, all vaccines tested in clinical trials to date have failed. Immunocompromised individuals such as patients with HIV or decreased levels of CD4+ T cells are highly susceptible to S. aureus infections, and they are also at increased risk of developing fungal infections. We therefore wondered whether stimulation of antifungal immunity might promote the type of immune responses needed for effective host defense again

SUBMITTER: Paterson MJ 

PROVIDER: S-EPMC7446838 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature