Antimalarial drug resistance molecular makers of Plasmodium falciparum isolates from Sudan during 2015-2017.

ABSTRACT:

Background

Current malaria control and elimination strategies rely mainly on efficacious antimalarial drugs. However, drug resistance is a major threat facing malaria control programs. Determination of drug resistance molecular markers is useful in the monitoring and surveillance of malaria drug efficacy. This study aimed to determine the mutations and haplotypes frequencies of different genes linked with antimalarial drug resistance in certain areas in Sudan.

Methods

A total of 226 dried blood spots (DBS) of microscopically diagnosed P. falciparum isolates were collected from Khartoum and three other areas in Sudan during 2015-2017. Plasmodium falciparum confirmation and multiplicity of infection was assessed using the Sanger's 101 SNPs-barcode and speciation was confirmed

SUBMITTER: Hussien M 

PROVIDER: S-EPMC7446868 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature