Racial differences in α4β7 expression on CD4+ T cells of HIV-negative men and women who inject drugs.

ABSTRACT:

Introduction

We performed a cross-sectional study of HIV-uninfected men and women who inject drugs from the ALIVE cohort to examine if black men and women who inject drugs have higher levels of CD4+ T cells expressing the integrin heterodimer α4β7 compared to white men and women.

Materials and methods

Flow cytometry was used to examine expression of α4β7 and other markers associated with different functional CD4+ T cell subsets in both men and women who inject drugs.

Results

Higher levels of α4β7, CCR5, and CCR6 were observed on CD4+ T cells from black participants compared with white participants. In a multivariable model, α4β7 expression differed by race, but not sex, age, or other factors.

Discussion

Black men and women express higher percentages of α4β7 exp

SUBMITTER: Martin AR 

PROVIDER: S-EPMC7447027 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature