The impact of HIV-1 subtypes on virologic and immunologic treatment outcomes at the Lagos University Teaching Hospital: A longitudinal evaluation.

ABSTRACT:

Introduction

HIV is a highly diverse virus with significant genetic variability which may confer biologic differences that could impact on treatment outcomes.

Materials and methods

We studied the association between HIV subtypes and immunologic and virologic outcomes in a longitudinal cohort of 169 patients on combination antiretroviral therapy. Participants were followed up for 5 years. Demographic data, CD4 cell count and viral loads (VL) were extracted from medical records. Whole protease gene and codon 1-300 of the reverse transcriptase gene were sequenced and analysed.

Results

Sixty-four percent of participants were females with a median age of 35 years. Twelve different subtypes were observed, the commonest being CRF 02_AG (55.0%) and subtypes G (23.1%). All sub

SUBMITTER: Ogbenna AA 

PROVIDER: S-EPMC7447033 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature