Sustained Focal Vascular Inflammation Accelerates Atherosclerosis in Remote Arteries.

ABSTRACT:

Objective

Evidence from preclinical and clinical studies has demonstrated that myocardial infarction promotes atherosclerosis progression. The impact of focal vascular inflammation on the progression and phenotype of remote atherosclerosis remains unknown. Approach and Results: We used a novel ApoE^-/- knockout mouse model of sustained arterial inflammation, initiated by mechanical injury in the abdominal aorta. Using serial in vivo molecular MRI and ex vivo histology and flow cytometry, we demonstrate that focal arterial inflammation triggered by aortic injury, accelerates atherosclerosis in the remote brachiocephalic artery. The brachiocephalic artery atheroma had distinct histological features including increased plaque size, plaque permeability, necrotic core t

SUBMITTER: Lavin Plaza B 

PROVIDER: S-EPMC7447189 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature