Genetic variants and functional pathways associated with resilience to Alzheimer's disease.

ABSTRACT: Approximately 30% of older adults exhibit the neuropathological features of Alzheimer's disease without signs of cognitive impairment. Yet, little is known about the genetic factors that allow these potentially resilient individuals to remain cognitively unimpaired in the face of substantial neuropathology. We performed a large, genome-wide association study (GWAS) of two previously validated metrics of cognitive resilience quantified using a latent variable modelling approach and representing better-than-predicted cognitive performance for a given level of neuropathology. Data were harmonized across 5108 participants from a clinical trial of Alzheimer's disease and three longitudinal cohort studies of cognitive ageing. All analyses were run across all participants and repeated restricting

SUBMITTER: Dumitrescu L 

PROVIDER: S-EPMC7447518 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature