Serum 20S proteasome levels are associated with disease activity in MPO-ANCA-associated microscopic polyangiitis.

ABSTRACT:

Background

Proteasomes are found in both the cell nucleus and cytoplasm and play a major role in the ubiquitin-dependent and -independent non-lysosomal pathways of intracellular protein degradation. Proteasomes are also involved in the turnover of various regulatory proteins, antigen processing, cell differentiation, and apoptosis. To determine the diagnostic value of serum proteasome in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), we investigated patients with AAV at various stages of the disease.

Methods

Serum 20S-proteasome was measured by ELISA in 44 patients with MPO-ANCA-associated microscopic polyangiitis (MPA) and renal involvement. Thirty of the patients provided serum samples before the initial treatment, and 30 provided samples during re

SUBMITTER: Maruyama H 

PROVIDER: S-EPMC7447580 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature