HDNA methylation data-based molecular subtype classification related to the prognosis of patients with hepatocellular carcinoma.

ABSTRACT:

Background

DNA methylation is a common chemical modification of DNA in the carcinogenesis of hepatocellular carcinoma (HCC).

Methods

In this bioinformatics analysis, 348 liver cancer samples were collected from the Cancer Genome Atlas (TCGA) database to analyse specific DNA methylation sites that affect the prognosis of HCC patients.

Results

10,699 CpG sites (CpGs) that were significantly related to the prognosis of patients were clustered into 7 subgroups, and the samples of each subgroup were significantly different in various clinical pathological data. In addition, by calculating the level of methylation sites in each subgroup, 119 methylation sites (corresponding to 105 genes) were selected as specific methylation sites within the subgroups. Moreover, genes in th

SUBMITTER: He H 

PROVIDER: S-EPMC7447581 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature