Nup133 and ERα mediate the differential effects of hyperoxia-induced damage in male and female OPCs.

ABSTRACT:

Background

Hyperoxia is a well-known cause of cerebral white matter injury in preterm infants with male sex being an independent and critical risk factor for poor neurodevelopmental outcome. Sex is therefore being widely considered as one of the major decisive factors for prognosis and treatment of these infants. But unfortunately, we still lack a clear view of the molecular mechanisms that lead to such a profound difference. Hence, using mouse-derived primary oligodendrocyte progenitor cells (OPCs), we investigated the molecular factors and underlying mechanisms behind the differential response of male and female cells towards oxidative stress.

Results

We demonstrate that oxidative stress severely affects cellular functions related to energy metabolism, stress response, and

SUBMITTER: Sunny DE 

PROVIDER: S-EPMC7447710 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature