Vitamin D ameliorates adipose browning in chronic kidney disease cachexia.

ABSTRACT: Patients with chronic kidney disease (CKD) are often 25(OH)D₃ and 1,25(OH)₂D₃ insufficient. We studied whether vitamin D repletion could correct aberrant adipose tissue and muscle metabolism in a mouse model of CKD-associated cachexia. Intraperitoneal administration of 25(OH)D₃ and 1,25(OH)₂D₃ (75 μg/kg/day and 60 ng/kg/day respectively for 6 weeks) normalized serum concentrations of 25(OH)D₃ and 1,25(OH)₂D₃ in CKD mice. Vitamin D repletion stimulated appetite, normalized weight gain, and improved fat and lean mass content in CKD mice. Vitamin D supplementation attenuated expression of key molecules involved in adipose tissue browning and ameliorated expression of thermogenic genes in adipose

SUBMITTER: Cheung WW 

PROVIDER: S-EPMC7447759 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature