Plasma cell-free DNA methylation marks for episodic memory impairment: a pilot twin study.

ABSTRACT: Decline in episodic memory performance usually causes the first clinical symptoms of Alzheimer's disease. At present, Alzheimer's disease can only be diagnosed at a very late stage when neurodegeneration and cognitive impairment is already irreversible. New early disease markers are needed for earlier and more efficient Alzheimer's disease intervention. To identify early disease markers, we implemented a genome-wide bisulphite sequencing method for the analysis of plasma cell-free DNA methylation profiles and compared differences associated with episodic memory performance in Finnish twin pairs. A noticeable amount of cell-free DNA was present in plasma, however, the amounts as well as the genomic coverage of these fragments varied substantially between individuals. We found no significant

SUBMITTER: Konki M 

PROVIDER: S-EPMC7447764 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature