Assessment of aPTT-based clot waveform analysis for the detection of haemostatic changes in different types of infections.

ABSTRACT: Infections cause varying degrees of haemostatic dysfunction which can be detected by clot waveform analysis (CWA), a global haemostatic marker. CWA has been shown to predict poor outcomes in severe infections with disseminated intravascular coagulopathy. The effect of less severe bacterial and viral infections on CWA has not been established. We hypothesized that different infections influence CWA distinctively. Patients admitted with bacterial infections, dengue and upper respiratory tract viral infections were recruited if they had an activated partial thromboplastin time (aPTT) measured on admission. APTT-based CWA was performed on Sysmex CS2100i automated analyser using Dade Actin FSL reagent. CWA parameters [(maximum velocity (min1), maximum acceleration (min2) and maximum deceleratio

SUBMITTER: Tan CW 

PROVIDER: S-EPMC7447776 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature